import { useState } from "react"; export default function EarAwareEARRNDPage() { const [openFAQ, setOpenFAQ] = useState(0); const faqs = [ { q: "Is the supplement a substitute for earplugs?", a: "No. Any future product is an adjunct to physical protection. Earplugs—and safe listening practices—remain essential.", }, { q: "What is EARRND?", a: "EARRND (Ear Research & New Development) is an independent research company partnering with EarAware to fund, design, and validate science-backed hearing-protection solutions.", }, { q: "Who can apply to the RFP?", a: "Academic labs, biotech startups, nutraceutical developers, CROs, and consortia with relevant expertise in otology, neuroscience, pharmacology, formulations, and clinical trials.", }, { q: "What’s the funding range?", a: "Initial grants typically range from $100,000–$500,000 depending on scope and feasibility, with potential for multi‑million‑dollar follow‑on investment contingent on results.", }, { q: "When is the deadline?", a: "Insert your specific submission deadline. We recommend 60–90 days from announcement for Phase 1 applications.", }, ]; const pillars = [ { title: "Glutamate Regulation", body: "Limit excitotoxic synaptic damage at inner hair cell–auditory nerve junctions while supporting healthy neurotransmission.", }, { title: "Oxidative Stress Reduction", body: "Counter reactive oxygen/nitrogen species triggered by loud sound using evidence‑based antioxidant strategies.", }, { title: "Mitochondrial Support", body: "Enhance cellular energy resilience in cochlear cells and reduce apoptosis during/after high‑level noise exposure.", }, { title: "Neuroprotection", body: "Preserve synapses (hidden hearing loss target), stabilize neural signaling, and maintain auditory performance.", }, ]; const prototype = [ { group: "Antioxidants", items: ["N‑acetylcysteine (NAC)", "Alpha‑lipoic acid", "Vitamin C/E (liposomal)", "Astaxanthin"], }, { group: "Neuroprotectives", items: ["Magnesium", "Resveratrol", "Acetyl‑L‑Carnitine", "Curcumin derivatives"], }, { group: "Mitochondrial Support", items: ["Coenzyme Q10 (ubiquinol)", "Omega‑3s (DHA/EPA)"] }, { group: "Bioavailability", items: ["Piperine (black pepper extract)"] }, ]; return (
{/* Hero */}
New Partnership

EarAware partners with EARRND to fund hearing‑protection research

We’re investing in science to help protect ears in high‑noise settings—concerts, clubs, festivals—by supporting the development of a safe, evidence‑based nutraceutical to be used alongside earplugs and safe listening.

This initiative advances research; it does not endorse any product currently on the market.

Research Pillars
Antioxidants · Neuroprotection · Mitochondria · Synapses
{/* Partnership summary */}

Why this partnership?

EarAware focuses on education and advocacy. EARRND is an independent R&D partner dedicated to translating laboratory science into accessible, real‑world hearing‑protection tools. Together, we’re supporting research on a nutraceutical designed for daily ear wellness and pre‑event “boost” use.

{pillars.map((p, i) => (
{p.title}

{p.body}

))}
{/* Prototype formula */}

Prototype formula (illustrative only)

This concept blend shows the multi‑pathway approach we want researchers to evaluate. Teams are encouraged to propose novel, synergistic alternatives grounded in strong evidence.

{prototype.map((g, idx) => (
{g.group}
    {g.items.map((it, j) => (
  • {it}
    • ))}
))}

*These are research examples, not medical advice or product claims. Final formulations will depend on study outcomes and safety reviews.

What success looks like

  • ✔ Reduced temporary/permanent threshold shifts in noise models
  • ✔ Preserved synaptic counts (hidden hearing loss target)
  • ✔ Biomarker changes: oxidative stress, inflammatory mediators
  • ✔ Fast absorption suitable for pre‑event use (1–2h window)
  • ✔ GRAS‑leaning safety profile and minimal interactions
  • ✔ Affordable, scalable manufacturing and access pathways
{/* RFP section */}

Request for Proposals (RFP)

EARRND invites proposals for a nutraceutical that reduces oxidative stress, regulates glutamate excitotoxicity, and preserves synaptic integrity in high‑noise environments. Projects should include pre‑clinical efficacy, safety, and a plan for human validation.

Required sections
  • Executive summary
  • Rationale & prior evidence
  • Methods & experimental design
  • Timeline & milestones
  • Budget & team qualifications
Key criteria
  • Mechanistic plausibility (glutamate · ROS · mitochondria · neuroprotection)
  • Evidence in NIHL models & relevant biomarkers
  • Safety (GRAS preferred), PK/PD, interactions
  • Scalable, affordable formulation

Replace the buttons above with your actual links (RFP PDF & submission portal/email).

{/* Safety & ethics */}

Safety, ethics, and transparency

  • \u2022 The initiative supports research. No product claims are made or implied.
  • \u2022 Any future supplement must be evidence‑based and undergo appropriate safety review.
  • \u2022 Earplugs and safe listening remain foundational to hearing protection.
  • \u2022 Research results (positive or negative) will inform public education and access pathways.

Contact

Media & general inquiries (EarAware): hello@earaware.org

Research proposals (EARRND): proposals@earrnd.org

Replace with your live emails/links.

{/* Press snippet */}

Press announcement

EarAware and EARRND have launched a call for innovative hearing‑protection research to create a supplement designed for high‑noise environments. The program funds rigorous science and prioritizes public accessibility.

Quote (placeholder)

“For too long, people have said, ‘I wish I had known this before.’ We’re pairing education with research to change that.”

— Add official spokesperson

{/* Footer */}
); }